*
THIS COMPLETE SOURCE MAY BE READ AT THE WEB ADDRESS BELOW
https://tinyurl.com/ybzubdfh
*
MEDICAL: DISEASES :
PHYSICAL EXERCISE AND FITNESS :
CHILDREN:
A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition
*
*
A Teen’s Muscle Soreness Turned Out to Be This Life-Threatening Condition
By Rachael Rettner, Senior Writer
June 4, 2018 05:22pm ET
https://www.livescience.com/62738-teen-muscle-soreness-rhabdomyolysis.html
*
*
A Texas teen who felt extremely sore after a hard gym workout turned out to have a rare and potentially life-threatening condition called rhabdomyolysis. But how do you tell the difference between run-of-the-mill soreness and rhabdomyolysis?
.
The teen, Jared Shamburger, had recently signed up for a gym membership with his family, according to local news outlet KTRK. His older brother and dad had been weightlifting for years, and Shamburger wanted to “catch up” with them. “I have to go hard fast,” Shamburger, who is 17, told KTRK.
.
But after a 90-minute weightlifting session, Shamburger said he felt particularly sore. “Everything hurt. It hurt to the touch. It was swollen,” he said.
.
When the teen’s soreness and swelling didn’t go away, his mom, Judy Shamburger, looked up his symptoms online, and realized her son might have rhabdomyolysis. Her suspicion was right. The teen was diagnosed with the condition, sometimes referred to as “rhabdo,” and hospitalized for five days, KTRK reported.
*
snip
*
Shamburger is expected to make a full recovery, KTRK reported.
*
*
Rhabdomyolysis – Wikipedia
https://en.wikipedia.org/wiki/Rhabdomyolysis
Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly.[3] Symptoms may include muscle pains, weakness, vomiting, and confusion.[3][4] There may be tea-colored urine or an irregular heartbeat.[3] Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.[3]
The muscle damage is most often the result of a crush injury, strenuous exercise, medications, or drug abuse.[3] Other causes include infections, electrical injury, heat stroke, prolonged immobilization, lack of blood flow to a limb, or snake bites.[3] Some people have inherited muscle conditions that increase the risk of rhabdomyolysis.[3] The diagnosis is supported by a urine test strip which is positive for “blood” but the urine contains no red blood cells when examined with a microscope.[3] Blood tests show a creatine kinase greater than 1,000 U/L, with severe disease being above 5,000 U/L.[5]
The mainstay of treatment is large quantities of intravenous fluids.[3] Other treatments may include dialysis or hemofiltration in more severe cases.[4][6] Once urine output is established sodium bicarbonate and mannitol are commonly used but they are poorly supported by the evidence.[3][4] Outcomes are generally good if treated early.[3] Complications may include high blood potassium, low blood calcium, disseminated intravascular coagulation, and compartment syndrome.[3]
Rhabdomyolysis occurs in about 26,000 people a year in the United States.[3] While the condition has been commented on throughout history, the first modern description was following an earthquake in 1908.[7] Important discoveries as to its mechanism were made during the Blitz of London in 1941.[7] It is a significant problem for those injured in earthquakes and relief efforts for such disasters often include medical teams equipped to treat survivors with rhabdomyolysis.[7]
Contents
1 Signs and symptoms
2 Causes
2.1 Genetic predisposition
3 Mechanism
4 Diagnosis
4.1 General investigations
4.2 Complications
4.3 Underlying disorders
5 Treatment
5.1 Electrolytes
5.2 Acute kidney impairment
5.3 Other complications
6 Prognosis
7 Epidemiology
8 History
9 Etymology and pronunciation
10 Other animals
11 References
12 External links
*
*
Rhabdomyolysis
Medline Plus
https://medlineplus.gov/ency/article/000473.htm
Rhabdomyolysis
Email this page to a friend Print Facebook Twitter Google+
Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. These substances are harmful to the kidney and often cause kidney damage.
Causes
When muscle is damaged, a protein called myoglobin is released into the bloodstream. It is then filtered out of the body by the kidneys. Myoglobin breaks down into substances that can damage kidney cells.
Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle.
Problems that may lead to this disease include:
Trauma or crush injuries
Use of drugs such as cocaine, amphetamines, statins, heroin, or PCP
Genetic muscle diseases
Extremes of body temperature
Ischemia or death of muscle tissue
Low phosphate levels
Seizures or muscle tremors
Severe exertion, such as marathon running or calisthenics
Lengthy surgical procedures
Severe dehydration
Muscle DisordersMuscle DisordersRead more
NIH MedlinePlus MagazineNIH MedlinePlus MagazineRead more
Health Topics A-ZHealth Topics A-ZRead more
A.D.A.M Quality Logo
Symptoms
Symptoms may include:
Dark, red, or cola-colored urine
Decreased urine output
General weakness
Muscle stiffness or aching (myalgia)
Muscle tenderness
Weakness of the affected muscles
Other symptoms that may occur with this disease:
Fatigue
Joint pain
Seizures
Weight gain (unintentional)
Exams and Tests
A physical exam will show tender or damaged skeletal muscles.
The following tests may be done:
Creatine kinase (CK) level
Serum calcium
Serum myoglobin
Serum potassium
Urinalysis
Urine myoglobin test
This disease may also affect the results of the following tests:
CK isoenzymes
Serum creatinine
Urine creatinine
Treatment
You will need to get fluids containing bicarbonate to help prevent kidney damage. You may need to get fluids through a vein (IV). Some people may need kidney dialysis.
Your health care provider may prescribe medicines including diuretics and bicarbonate (if there is enough urine output).
Hyperkalemia and low blood calcium levels (hypocalcemia) should be treated right away. Kidney failure should also be treated.
Outlook (Prognosis)
The outcome depends on the amount of kidney damage. Acute kidney failure occurs in many people. Getting treated soon after rhabdomyolysis will reduce the risk of permanent kidney damage.
People with milder cases may return to their normal activities within a few weeks to a month. However, some people continue to have problems with fatigue and muscle pain.
Possible Complications
Complications may include:
Acute tubular necrosis
Acute renal failure
Harmful chemical imbalances in the blood
Shock (low blood pressure)
When to Contact a Medical Professional
Call your provider if you have symptoms of rhabdomyolysis.
Prevention
Rhabdomyolysis can be avoided by:
Drinking plenty of fluids after strenuous exercise.
Removing extra clothes and immersing the body in cold water in case of heat stroke.
Images
Male urinary systemMale urinary system
References
O’Connor FG, Deuster PA. Rhabdomyolysis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 113.
Parekh R. Rhabdomyolysis. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 119.
Uduman J, Singasani R. Rhabdomyolysis. In: Ferri FF, ed. Ferri’s Clinical Advisor 2018. Philadelphia, PA: Elsevier; 2018:1122-1124.
Review Date 8/1/2017
Updated by: Walead Latif, MD, nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC’s accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.’s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsements of those other sites. Copyright 1997-2018, A.D.A.M., Inc. Duplication for commercial use must be authorized in writing by ADAM Health Solutions.
*
*
Rhabdomyolysis
PUBMED Health
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024696/
Rhabdomyolysis
Rhabdomyolysis is a condition in which damaged skeletal muscle tissue breaks down rapidly. Breakdown products of damaged muscle cells are released into the bloodstream. Some of these, such as the protein myoglobin, are harmful to the kidneys and may lead to kidney failure.
PubMed Health Glossary
(Source: Wikipedia)
About Rhabdomyolysis
Rhabdomyolysis is an extremely rare but serious side effect where muscle tissue gradually breaks down in certain muscles. This can lead to permanent paralysis, and the breakdown products can cause serious kidney damage.
In studies, rhabdomyolysis was found to occur in 1 out of 10,000 people who took statins for longer periods of time.
Signs of this side effect include muscle ache and dark-colored urine, so it is important to seek medical advice if you have these symptoms. Institute for Quality and Efficiency in Health Care (IQWiG)
ults: 1 to 20 of 60
Is continuous renal replacement therapy beneficial for people with rhabdomyolysis?
Rhabdomyolysis is a potentially life-threatening condition where damaged muscle tissue breaks down quickly, and products of damaged muscle cells are released into the bloodstream. Of these products, a protein called myoglobin is harmful to kidney health and can lead to acute kidney injury. There is some evidence to suggest that continuous renal replacement therapy (CRRT) may provide benefits for people with rhabdomyolysis.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: June 15, 2014
Rhabdomyolysis in bariatric surgery: a systematic review
BACKGROUND: Rhabdomyolysis (RML) is a rare complication of bariatric surgery. A systematic review was performed to identify risk factors and patient outcomes in morbidly obese patients undergoing bariatric surgery who develop RML.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013
Prevention of kidney injury following rhabdomyolysis: a systematic review
OBJECTIVE: To conduct a systematic literature review to evaluate evidence-based recommendations for the prevention of rhabdomyolysis-associated acute renal failure (ARF).
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013
Statin-induced rhabdomyolysis: a comprehensive review of case reports
PURPOSE: To identify case reports of statin-induced rhabdomyolysis and summarize common predisposing factors, symptoms, diagnostic findings, functional outcomes, characteristics, treatment, and rehabilitation.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2014
Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review
This review concluded that there was inadequate evidence to evaluate use of urine myoglobin as a predictor of acute renal failure in patients with suspected rhabdomyolysis. There were limitations in the review and included studies, but the overall conclusion reflected the evidence presented.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2009
Systematic review and meta-analysis of clinically relevant adverse events from HMG CoA reductase inhibitor trials worldwide from 1982 to present
PURPOSE: Our objective was to determine the association of clinically relevant adverse events from a systematic review and meta-analysis of statin randomized controlled trials (RCT).
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007
Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force [Internet]
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in the United States but is potentially preventable with statin therapy. The U.S. Preventive Services (USPSTF) commissioned this review to inform the development of new recommendations on use of statin therapy for prevention of CVD in adults.
Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: November 2016
Show search results within this document
Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis
The review concluded that both low- and high-potency statins were efficacious in preventing death and cardiovascular-related morbidity in people at low risk of cardiovascular events, although the number needed to treat to prevent one adverse outcome was relatively high for any statin. The authors’ conclusions reflect the evidence available and appear likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011
Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis
The use of statin therapy for cardiovascular disease was associated with a relatively low risk of adverse events. High risk of bias within the studies, high clinical and methodological heterogeneity between the studies, and a discrepancy between the initial outcomes stated and those actually reported suggest that the authors’ conclusions and recommendations may not be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2012
Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials
This review concluded that intensive-dose statin therapy reduced all-cause mortality in patients with recent acute coronary syndrome but not in patients with stable coronary heart disease, compared with moderate-dose statin therapy. The review was well-conducted and these conclusions are likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007
Lipid Modification: Cardiovascular Risk Assessment and the Modification of Blood Lipids for the Primary and Secondary Prevention of Cardiovascular Disease
This guideline updates for primary prevention, the NICE technology appraisal, Statins for the prevention of cardiovascular events (TA94, 2007) and reviews and updates the recommendations made in the NICE guideline Lipid Modification (CG67, 2008) for primary and secondary prevention of cardiovascular disease (CVD). The scope for this guideline was limited to the identification and assessment of CVD risk and to the assessment and modification of lipids in people at risk of CVD, or people with known CVD. The guideline development group wishes to make clear that lipid modification should take place as part of a programme of risk reduction which also include attention to the management of all other known CVD risk factors.
NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: July 2014
Show search results within this document
Aerobic training for McArdle disease
McArdle disease is a rare disease of muscle metabolism. Affected people cannot use a starch-like substance called glycogen which is stored in muscle and used for energy at the beginning of activity and during strenuous exercise. The effects of the condition are fatigue and cramping within a few minutes of starting an activity, which can potentially lead to acute muscle damage. After about seven or eight minutes of exercise the muscle can start to use alternative sources of energy from fats and sugars supplied from the liver and so the symptoms ease. This phenomenon is called the ‘second wind’. In healthy people, aerobic training is known to improve the ability of muscle to burn fats for energy during exercise. In theory then, aerobic training could be beneficial to people with McArdle disease, as their muscles might be trained to use fats earlier and more efficiently during exercise. The purpose of this review was to identify any randomised controlled trials of aerobic training and assess its effects in people with McArdle disease. There were no randomised controlled trials of aerobic training in people with McArdle disease. There were, however, three small uncontrolled studies (the largest included nine participants). The studies showed that it is possible for people with McArdle disease to undergo exercise training and there were no harmful effects. Whether or not training is beneficial for people with McArdle disease needs further investigation, with randomised controlled trials including larger numbers of people with the condition.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 7, 2011
Statins for acute ischemic stroke
Stroke is a major public health problem than can cause death and severe disability. A limited number of drugs are available for treating patients with stroke. Statins, a group of drugs commonly used to reduce cholesterol levels, are known to be safe and effective when given to patients with an acute heart attack. Therefore, they may also be beneficial in patients with acute stroke. We identified eight relevant trials of statins in acute stroke involving 625 participants. Unfortunately, insufficient information was available to establish whether statins are safe and beneficial for patients with acute ischemic stroke
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: August 10, 2011
Drug Class Review: HMG-CoA Reductase Inhibitors (Statins) and Fixed-dose Combination Products Containing a Statin: Final Report Update 5 [Internet]
In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 lives, translating into about 1 out of every 5 deaths in the United States. High levels of cholesterol, or hypercholesterolemia, are an important risk factor for coronary heart disease. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol concentrations. They are first-line agents for patients who require drug therapy to reduce serum low-density lipoprotein cholesterol concentrations. The purpose of this review is to compare the benefits and harms of different statins in adults and children with hypercholesterolemia.
Drug Class Reviews – Oregon Health & Science University.
Version: November 2009
Show search results within this document
Single-dose oral celecoxib for postoperative pain
Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. People with pain are used to test pain killers. They have often had wisdom teeth removed. The pain is often treated with pain killers given by mouth. Results can then be applied to other forms of acute pain.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: October 22, 2013
Lipid-lowering agents for nephrotic syndrome
Nephrotic syndrome is a relatively rare disease in which the kidneys leak protein into the urine. A common early sign is swelling in the feet and face. Other signs and symptoms of nephrotic syndrome include low levels of protein in the blood, and high levels of fats in the blood, particularly cholesterol and triglycerides.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 10, 2013
Drug and nutritional treatment for McArdle disease
We reviewed the evidence about the effects of drug and nutritional treatment for McArdle disease.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: November 12, 2014
Statins can help reduce risk of death in people with chronic kidney disease who do not need dialysis
Adults with chronic kidney disease (CKD) have high risks of developing complications from heart disease. It is thought that statin treatment lowers cholesterol and reduces risk of death and complications from heart disease.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: May 31, 2014
Screening for Lipid Disorders in Adults: Selective Update of 2001 US Preventive Services Task Force Review [Internet]
Both the US Preventive Services Task Force (USPSTF) and the National Cholesterol Education Program (NCEP ATP III) have issued recommendations on screening for dyslipidemia in adults. To guide the USPSTF in updating its 2001 recommendations, we reviewed evidence relevant to discrepancies between these recommendations.
Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: June 2008
Show search results within this document
The harmful health effects of recreational ecstasy: a systematic review of observational evidence
Street drugs known as ecstasy have been sold for about 20 years in the UK. The active substance that such tablets contain or purport to contain is 3,4-methylenedioxymethamphetamine (MDMA). Shortly after consumption, MDMA releases chemicals in the brain that tend to bring about a sense of euphoria, exhilaration and increased intimacy with others. It is thought to be the third most commonly used illegal drug in the UK after cannabis and cocaine, with estimates suggesting that between 500,000 and 2 million tablets are consumed each week. Most people who take ecstasy also use other legal and illegal drugs, sometimes at the same time. Ecstasy is commonly taken in nightclubs and at parties and is very often associated with extended sessions of dancing.
NIHR Health Technology Assessment programme: Executive Summaries – NIHR Journals Library.
Version: 2009
A systematic review and economic evaluation of statins for the prevention of coronary events
This study evaluated the use of a group of statins, atorvastatin, fluvastatin, pravastatin, rosuvastatin and simvastatin, for the prevention of cardiovascular events.
NIHR Health Technology Assessment programme: Executive Summaries – NIHR Journals Library.
Version: 2007
Lipid Screening in Childhood and Adolescence for Detection of Familial Hypercholesterolemia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]
Familial hypercholesterolemia (FH) is an inherited disorder of lipoprotein metabolism characterized by highly elevated total cholesterol (TC) concentrations early in life, independent of environmental influences. Around 1 in 200 to 1 in 500 persons in North America and Europe are estimated to have heterozygous FH. When untreated, FH is associated with a high incidence of premature clinical atherosclerotic cardiovascular disease.
Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: August 2016
Show search results within this document
Daptomycin for Methicillin-Resistant and Methicillin-Sensitive Staphylococcus Aureus Infection: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines [Internet]
The aim of this review is to summarize evidence on the comparative clinical and cost effectiveness of daptomycin to other antibiotics for the treatment of bacteremia and other infections caused by methicillin susceptible staphylococcus aureus (MSSA) or methicillin resistant staphylococcus aureus (MRSA), and to summarize evidence-based guidelines regarding the use of daptomycin for MRSA and MSSA bacteremia or infection.
Rapid Response Report: Summary with Critical Appraisal – Canadian Agency for Drugs and Technologies in Health.
Version: January 21, 2016
Show search results within this document
Lipid Screening in Childhood for Detection of Multifactorial Dyslipidemia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]
For purposes of this report, multifactorial dyslipidemia refers to dyslipidemias involving elevated total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) that are not familial hypercholesterolemia (FH). There is evidence that elevated TC and LDL-C concentrations in childhood, and especially adolescence, are associated with markers of atherosclerosis in young adults.
Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: August 2016
Show search results within this document
Screening for Dyslipidemia in Younger Adults: A Systematic Review to Update the 2008 U.S. Preventive Services Task Force Recommendation [Internet]
This review updates prior reviews on screening for lipid disorders in adults, and will be used by the U.S. Preventive Services Task Force (USPSTF) to update its 2008 recommendation. Unlike prior USPSTF reviews, this one focuses on screening in younger adults, defined as adults ages 21 to 39 years, as there is more uncertainty about the need to perform lipid screening in this population than in older adults.
Evidence Syntheses – Agency for Healthcare Research and Quality (US).
Version: November 2016
Show search results within this document
Chronic Kidney Disease (Partial Update): Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care
The Renal National Service Framework (NSF), and the subsequent NICE Clinical Practice Guideline for early identification and management of adults with chronic kidney disease (CKD) in primary and secondary care (CG73), served to emphasise the change in focus in renal medicine from treatment of established kidney disease to earlier identification and prevention of kidney disease.
NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: July 2014
Show search results within this document
Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection
These are the first World Health Organization (WHO) guidelines for the prevention, care and treatment of persons living with chronic hepatitis B (CHB) infection, and complement similar recently published guidance by WHO on the prevention, care and treatment of infection due to the hepatitis C virus (HCV).
World Health Organization.
Version: March 2015
Show search results within this document
Management of Gout [Internet]
To review the evidence base for treating patients with gout, both acute attacks and chronic disease. The review specifically focuses on the management of patients with gout in the primary care setting.
Comparative Effectiveness Reviews – Agency for Healthcare Research and Quality (US).
Version: March 2016
Show search results within this document
Spinal Injury: Assessment and Initial Management
The scope of this guideline is the assessment, imaging and early management of spinal injury and does not address rehabilitation. It is important to recognise that early management is intrinsically connected to rehabilitation and some later complications may be avoided with changes in early care. Early and ongoing collaborative multidisciplinary care across a trauma network is vital in ensuring that the patient with a spinal injury receives the best possible care.
NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document
Major Trauma: Assessment and Initial Management
This guideline provides guidance on the assessment and management of major trauma, including resuscitation following major blood loss associated with trauma. For the purposes of this guideline, major trauma is defined as an injury or a combination of injuries that are life-threatening and could be life changing because it may result in long-term disability. This guideline covers both the pre-hospital and immediate hospital care of major trauma patients but does not include any management after definitive lifesaving intervention. It has been developed for health practitioners and professionals, patients and carers and commissioners of health services.
NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document
Fractures (Complex): Assessment and Management
Two of the five guidelines in the NICE Trauma Suite relate to fractures. These are titled non-complex and complex fractures. In broad terms the non-complex fractures are those likely to be treated at the receiving hospital, whereas the complex fractures require transfer or the consideration of transfer of the injured person to a specialist centre.
NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document
Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation
The study was unable to compare the clinical and cost-effectiveness of platinum-based therapies with non-platinum-based therapies for platinum sensitive ovarian cancer. In people with platinum-sensitive disease, paclitaxel plus platinum could be considered cost-effective compared with platinum therapies alone at a threshold of 30,000 per additional quality-adjusted life-year. In people with disease which is resistant or refractory to platinum it is unlikely that topotecan would be considered cost-effective compared with pegylated liposomal doxorubicin hydrochloride.
Health Technology Assessment – NIHR Journals Library.
Version: January 2015
Show search results within this document
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet]
Alcohol is the most widely used psychotropic drug in the industrialised world; it has been used for thousands of years as a social lubricant and anxiolytic. In the UK, it is estimated that 24% of adult men and 13% of adult women drink in a hazardous or harmful way. Levels of hazardous and harmful drinking are lowest in the central and eastern regions of England (2124% of men and 1014% of women). They are highest in the north (2628% of men, 1618% of women). Hazardous and harmful drinking are commonly encountered amongst hospital attendees; 12% of emergency department attendances are directly related to alcohol whilst 20% of patients admitted to hospital for illnesses unrelated to alcohol are drinking at potentially hazardous levels. Continued hazardous and harmful drinking can result in dependence and tolerance with the consequence that an abrupt reduction in intake might result in development of a withdrawal syndrome. In addition, persistent drinking at hazardous and harmful levels can also result in damage to almost every organ or system of the body. Alcohol-attributable conditions include liver damage, pancreatitis and the Wernickes encephalopathy. Key areas in the investigation and management of these conditions are covered in this guideline.
NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: 2010
Show search results within this document
The Management of Lower Urinary Tract Symptoms in Men [Internet]
The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.
NICE Clinical Guidelines – National Clinical Guideline Centre (UK).
Version: 2010
Show search results within this document
Reslizumab (Cinqair) [Internet]
Asthma is a common chronic respiratory disorder characterized by reversible airway obstruction, pulmonary inflammation, airway hyper-responsiveness, and airway remodelling., Patients with asthma typically present with paroxysmal or persistent symptoms of wheezing, dyspnea, chest tightness, sputum production, and coughing that are associated with airflow limitation and airway hyper-responsiveness to endogenous and exogenous stimuli (e.g., exercise; viral respiratory infections; or exposure to certain allergens, irritants, or gases). Severe eosinophilic asthma is an asthma phenotype characterized by the presence of eosinophils in the airways and sputum, despite compliance with conventional asthma therapy. Severe asthma can have a profound effect on patients day-to-day lives, such as limiting physical activity, reducing performance at work or school, restricting social interactions, and leading to stigma. It may also necessitate frequent physician and emergency room visits.
Common Drug Review – Canadian Agency for Drugs and Technologies in Health.
Version: April 2017
Show search results within this document
When To Suspect Child Maltreatment
This guidance provides a summary of the clinical features associated with maltreatment (alerting features) that may be observed when a child presents to healthcare professionals. Its purpose is to raise awareness and help healthcare professionals who are not specialists in child protection to identify children who may be being maltreated. It does not give healthcare professionals recommendations on how to diagnose, confirm or disprove child maltreatment.
NICE Clinical Guidelines – National Collaborating Centre for Women’s and Children’s Health (UK).
Version: July 2009
Show search results within this document
Identification and Management of Familial Hypercholesterolaemia (FH) [Internet]
While the NHS in England and Wales has made spectacular progress in improving the secondary prevention of cardiovascular disease, we now need to work harder to identify those who are at particularly high risk of myocardial infarction.
NICE Clinical Guidelines – National Collaborating Centre for Primary Care (UK).
Version: August 2008
Show search results within this document
Lomitapide (Juxtapid) [Internet]
The objective of this review is to evaluate the beneficial and harmful effects of lomitapide added to other lipid-lowering therapy in patients with homozygous familial hypercholesterolemia (HoFH).
Common Drug Review – Canadian Agency for Drugs and Technologies in Health.
Version: July 2015
Show search results within this document
Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: a systematic review with statistical and cost-effectiveness modelling
The study found that regular lipid monitoring in individuals with and without cardiovascular disease is likely to be beneficial to both patients and to the health service, and frequent monitoring strategies appear to be cost-effective.
Health Technology Assessment – NIHR Journals Library.
Version: December 2015
Show search results within this document
Noninvasive Testing for Coronary Artery Disease [Internet]
This report evaluates the current state of evidence regarding effectiveness and harms of noninvasive technologies for the diagnosis of coronary artery disease (CAD) or dysfunction that results in symptoms attributable to myocardial ischemia in stable symptomatic patients who have no known history of CAD.
Comparative Effectiveness Reviews – Agency for Healthcare Research and Quality (US).
Version: March 2016
Show search results within this document
Major Trauma: Service Delivery
A trauma service provides care for people who have sustained physical injuries. These injuries are often the result of an accident but can be sustained in other circumstances. Injuries range from minor to serious life-threatening trauma. The scope of this guidance is the delivery of services for people with major trauma in the initial phase of care, exploring areas of uncertainty and variation.
NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document
Fractures (Non-Complex): Assessment and Management
Two of the five guidelines in the NICE trauma suite relate to fractures. These are titled non-complex and complex fractures. In broad terms, non-complex fractures are those likely to be treated at the receiving hospital, whereas complex fractures require transfer or the consideration of transfer of the injured person to a specialist.
NICE Guideline – National Clinical Guideline Centre (UK).
Version: February 2016
Show search results within this document
Antisocial Behaviour and Conduct Disorders in Children and Young People: Recognition, Intervention and Management
Antisocial behaviour and conduct disorders are the most common reason for referral to child and adolescent mental health services and have a significant impact on the quality of life of children and young people and their parents and carers. Rates of other mental health problems (including antisocial personality disorder) are considerably increased for adults who had a conduct disorder in childhood. This new NICE guideline seeks to address these problems by offering advice on prevention strategies, as well as a range of psychosocial interventions.
NICE Clinical Guidelines – National Collaborating Centre for Mental Health (UK).
Version: 2013
Show search results within this document
Meta-analysis of safety of the coadministration of statin with fenofibrate in patients with combined hyperlipidemia
Addition of fenofibrate to statin therapy might represent a viable treatment option for patients whose high risk for coronary heart disease is not controlled by a statin alone. However, safety of coadministration of statin with fenofibrate has been a great concern. The present study tested the safety of coadministration of statin with fenofibrate. We systematically searched the literature to identify randomized controlled trials examining safety of coadministration of statin with fenofibrate. A meta-analysis was performed to estimate safety of coadministration of statin with fenofibrate using fixed-effects models. There were 1,628 subjects in the identified 6 studies. Discontinuation attributed to any adverse events (4.5% vs 3.1%, p = 0.20), any adverse events (42% vs 41%, p = 0.82), adverse events related to study drug (10.9% vs 11.0%, p = 0.95), and serious adverse events (2.0% vs 1.5%, p = 0.71) were not significantly different in the 2 arms. Incidence of alanine aminotransferase and/or aspartate aminotransferase =3 times upper limit of normal in the combination therapy arm was significantly higher than in the statin monotherapy arm (3.1% vs 0.2%, p = 0.0009). In the 6 trials with 1,628 subjects no case of myopathy or rhabdomyolysis was reported. In conclusion, statin-fenofibrate combination therapy was tolerated as well as statin monotherapy. Physicians should consider statin-fenofibrate combination therapy to treat patients with mixed dyslipidemia.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2012
Efficacy and safety evaluation of intensive statin therapy in older patients with coronary heart disease: a systematic review and meta-analysis
PURPOSE: To reveal and evaluate the efficacy and safety of intensive statin therapy in older patients (age = 65 years) with coronary heart disease (CHD).
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2013
A systematic review and economic evaluation of statins for the prevention of coronary events
OBJECTIVES: To evaluate the clinical effectiveness and cost-effectiveness of statins for the primary and secondary prevention of cardiovascular events in adults with, or at risk of, coronary heart disease (CHD).
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007
Risks associated with statin therapy: a systematic overview of randomized clinical trials
This review evaluated the risk of adverse events among patients taking statins. The authors concluded that statin therapy in carefully selected patients is associated with low adverse event rates in clinical trials. The reliability of the results is unclear given the lack of detail about the review process and potential for bias.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006
Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients
This review concluded that statin treatment used for the primary prevention of cardiovascular disease was effective in reducing cardiovascular death and other major cardiovascular events. The conduct and reporting of the review were good and the conclusions are likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2008
Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40,000 patients
This review found that intensive dosing with statins for prevention of cardiovascular events was associated with significant reductions in non-fatal events. The review was well conducted and the authors’ conclusions are likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
This prospective meta-analysis of individual patient data concluded that statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation and stroke by about 20% per mmol/L reduction in cholesterol, largely irrespective of lipid profile or other characteristics. The authors’ conclusions reflect the evidence presented and are likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2005
Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy
The authors concluded that intensive-dose statin therapy significantly reduced the risk of a serious cardiovascular event but increased the risk of a statin-induced adverse event, compared with moderate dose therapy. The reliability of these conclusions is uncertain due to methodological weaknesses in the review such as failure to assess study validity or check for heterogeneity between the studies.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007
Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials
This review concluded that statin therapies offered clear benefits in reducing cardiovascular outcomes across broad populations. The review appeared generally well conducted. The authors conclusions appear likely to be reliable, although it should be borne in mind that subgroup analysis by population type was conducted only for the primary outcome of cardiovascular disease mortality.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2011
The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials
This review investigated the effects of early intensive statin therapy for acute coronary syndrome. It concluded that early treatment reduces cardiovascular events with benefits observed after 6 months, but an analysis of individual patient data is needed to confirm these findings. The pooled results should be regarded with some caution because of limitations such as the variation between study results.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials
This meta-analysis of individual patient data found that reducing low-density lipoprotein cholesterol with statins reduced the annual rate of heart attack, revascularisation and stroke by about 20% for each 1mmol/litre reduction achieved. These conclusions reflected the strong evidence presented and are likely to be reliable and applicable to a wide range of patients.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2010
Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy
The authors concluded that intensive statin treatment offers greater benefits than standard-dose treatment, mainly for nonfatal cardiovascular events. The review appears to support the authors’ conclusions, but the poor reporting of review methods and the lack of an assessment of study quality mean that the reliability of the conclusions is uncertain.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006
The clinical and cost-effectiveness of intensive versus standard lipid lowering with statins in the prevention of cardiovascular events amongst patients with acute coronary syndromes: a systematic review
Early intensive lipid lowering with high-dose/potency statins for high risk acute coronary syndrome (ACS) patients significantly reduced the risk of death or major cardiovascular event in comparison with standard lipid lowering regimens. The authors’ conclusion is reasonable, but perhaps should be tempered as it was primarily based on one large trial and generalisability beyond that intervention might be premature.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2007
Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies
This review determined the evidence on the use of statins during the peri-operative period to reduce the risk of cardiovascular events. The authors concluded that there was insufficient evidence for routine administration of statins to reduce peri-operative cardiovascular risk. Given the limitations of the evidence base, this conclusion seems reasonable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006
Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials
This review assessed the effects of starting statin therapy within 14 days of the onset of acute coronary syndrome. The authors concluded that early statin therapy does not reduce death, myocardial infarction or stroke up to 4 months, but may reduce unstable angina. This was a well-conducted and clearly reported review and the authors’ conclusions are likely to be reliable.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2006
Comparison of sequential rosuvastatin doses in hypercholesterolaemia: a meta-analysis of randomised controlled trials
This review provided evidence for improved efficacy, as assessed by surrogate markers, in treating patients with hypercholesterolaemia with each sequential titration of rosuvastatin and a generally consistent tolerability profile across the dose range. The authors’ conclusions reflect the evidence presented, but the lack of validity assessment and lack of reporting of some data made the reliability of the conclusions uncertain.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2010
Systematic review: comparative effectiveness and harms of combinations of lipid-modifying agents and high-dose statin monotherapy
This review concluded that there was insufficient evidence to support the benefit for mortality, myocardial infarction, stroke, and revascularisation procedures of statin combination therapy over high-dose monotherapy in high-risk patients needing intensive lipid-lowering therapy. The authors’ conclusion reflected the evidence presented, but the reliability is potentially compromised by search restrictions and unclear quality of included studies.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] – Centre for Reviews and Dissemination (UK).
Version: 2009
Results: 10
Is continuous renal replacement therapy beneficial for people with rhabdomyolysis?
Rhabdomyolysis is a potentially life-threatening condition where damaged muscle tissue breaks down quickly, and products of damaged muscle cells are released into the bloodstream. Of these products, a protein called myoglobin is harmful to kidney health and can lead to acute kidney injury. There is some evidence to suggest that continuous renal replacement therapy (CRRT) may provide benefits for people with rhabdomyolysis.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: June 15, 2014
When is it worth taking statins to lower high cholesterol?
High cholesterol levels could mean an increased risk of cardiovascular disease. Certain medications called statins lower the amount of cholesterol in the blood. They can prevent related medical conditions and increase life expectancy. Whether or not it’s worth taking them will depend on what other risk factors you have, though. If the risk of cardiovascular disease can’t be reduced enough through general measures, treatment with medication can be considered. Whether treatment with medication is a good idea will mostly depend on individual risk factors and how you yourself view the pros and cons of the treatment. The main factor is whether you have already had cardiovascular disease, such as coronary artery disease. That may greatly increase the risk of a heart attack or stroke. This risk can be reduced using medication. When deciding whether or not to have a certain treatment, it can help to find out about the advantages and disadvantages of the treatment. Various groups of drugs can be used for the treatment of high cholesterol. But only one group of drugs, known as statins, has been well studied in people who have never had a heart attack, stroke or other type of cardiovascular disease. Many different statins have been approved in Germany, including atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin.
Informed Health Online [Internet] – Institute for Quality and Efficiency in Health Care (IQWiG).
Version: September 7, 2017
Medication for the long-term treatment of coronary artery disease
The long-term treatment of coronary artery disease (CAD) mainly involves taking medication. Various medications can relieve the symptoms and lower the risk of complications. In order to prevent the development of related medical conditions, all people who have coronary artery disease (CAD) are advised to take two types of medication: Antiplatelets to prevent blood clots, and statins to protect the blood vessels. Beta blockers are sometimes taken too, to reduce the heart’s workload, particularly in people who have heart failure or high blood pressure. Good-quality studies have proven that these medications can lower the risk of complications such as heart attacks or strokes. People who have certain other medical conditions too may take other medications such as ACE inhibitors. But even the very best treatment with medications will offer only limited protection from heart disease. All medications can have side effects. Yet it is often possible to avoid them by adjusting the dose or by choosing a different medication in the same group of drugs. The side effects often go away after a while too, once the body has got used to the medication. The risk of side effects may increase when two or more medications are taken together, because they may interact. It is therefore important to tell your doctor what medication you are already taking. Generally speaking, the more risk factors someone has, the more likely it is that he or she will benefit from medication. The important thing is to continue to take your medication and to take it regularly its protective effect lasts only as long as it is taken.
Informed Health Online [Internet] – Institute for Quality and Efficiency in Health Care (IQWiG).
Version: July 27, 2017
Aerobic training for McArdle disease
McArdle disease is a rare disease of muscle metabolism. Affected people cannot use a starch-like substance called glycogen which is stored in muscle and used for energy at the beginning of activity and during strenuous exercise. The effects of the condition are fatigue and cramping within a few minutes of starting an activity, which can potentially lead to acute muscle damage. After about seven or eight minutes of exercise the muscle can start to use alternative sources of energy from fats and sugars supplied from the liver and so the symptoms ease. This phenomenon is called the ‘second wind’. In healthy people, aerobic training is known to improve the ability of muscle to burn fats for energy during exercise. In theory then, aerobic training could be beneficial to people with McArdle disease, as their muscles might be trained to use fats earlier and more efficiently during exercise. The purpose of this review was to identify any randomised controlled trials of aerobic training and assess its effects in people with McArdle disease. There were no randomised controlled trials of aerobic training in people with McArdle disease. There were, however, three small uncontrolled studies (the largest included nine participants). The studies showed that it is possible for people with McArdle disease to undergo exercise training and there were no harmful effects. Whether or not training is beneficial for people with McArdle disease needs further investigation, with randomised controlled trials including larger numbers of people with the condition.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 7, 2011
Statins for acute ischemic stroke
Stroke is a major public health problem than can cause death and severe disability. A limited number of drugs are available for treating patients with stroke. Statins, a group of drugs commonly used to reduce cholesterol levels, are known to be safe and effective when given to patients with an acute heart attack. Therefore, they may also be beneficial in patients with acute stroke. We identified eight relevant trials of statins in acute stroke involving 625 participants. Unfortunately, insufficient information was available to establish whether statins are safe and beneficial for patients with acute ischemic stroke
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: August 10, 2011
Single-dose oral celecoxib for postoperative pain
Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. People with pain are used to test pain killers. They have often had wisdom teeth removed. The pain is often treated with pain killers given by mouth. Results can then be applied to other forms of acute pain.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: October 22, 2013
Lipid-lowering agents for nephrotic syndrome
Nephrotic syndrome is a relatively rare disease in which the kidneys leak protein into the urine. A common early sign is swelling in the feet and face. Other signs and symptoms of nephrotic syndrome include low levels of protein in the blood, and high levels of fats in the blood, particularly cholesterol and triglycerides.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: December 10, 2013
Drug and nutritional treatment for McArdle disease
We reviewed the evidence about the effects of drug and nutritional treatment for McArdle disease.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: November 12, 2014
Statins can help reduce risk of death in people with chronic kidney disease who do not need dialysis
Adults with chronic kidney disease (CKD) have high risks of developing complications from heart disease. It is thought that statin treatment lowers cholesterol and reduces risk of death and complications from heart disease.
Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] – John Wiley & Sons, Ltd.
Version: May 31, 2014
Comparing Statins and Combination Drugs
How do statins and combination drugs compare in lowering “bad” cholesterol (LDL-c)?
PubMed Clinical Q&A [Internet] – National Center for Biotechnology Information (US).
Version: November 1, 2010
https://www.ncbi.nlm.nih.gov/pubmedhealth/c/pmh_cons/?term=rhabdomyolysis
*
*
What’s to know about rhabdomyolysis?
Last reviewed Wed 5 July 2017
By Jennifer Huizen
Medical News Today
https://www.medicalnewstoday.com/articles/318224.php
Article Contents
What is rhabdomyolysis?
Causes
Symptoms
Diagnosis
Treatment
Preventing rhabdomyolysis
*
*
Rhabdomyolysis
Updated: Nov 10, 2017
Author
Eyal Muscal, MD, MS Assistant Professor, Section of Pediatric Immunology, Allergy, and Rheumatology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital
Eyal Muscal, MD, MS is a member of the following medical societies: Alpha Omega Alpha, American College of Rheumatology
Disclosure: Nothing to disclose.
Coauthor(s)
Marietta Morales De Guzman, MD Associate Professor, Section of Immunology, Allergy and Rheumatology, Department of Pediatrics, Baylor College of Medicine; Clinic Chief, Pediatric Rheumatology Center, Texas Children’s Hospital
Marietta Morales De Guzman, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology, Texas Pediatric Society
Disclosure: Nothing to disclose.
Chief Editor
Lawrence K Jung, MD Chief, Division of Pediatric Rheumatology, Children’s National Medical Center
Medscape
https://emedicine.medscape.com/article/1007814-overview
In most cases, the history reflects the inciting cause (though in some, it is nonspecific and thus diagnostically unreliable). Possible causes include the following:
Alcohol use and resultant unresponsiveness
Illicit drug use
Use of prescribed medications
Heatstroke
Infection
Trauma
Metabolic disorders
Inflammatory myopathies
Initial physical findings may be nonspecific. The following may be noted:
Muscular pain and tenderness
Decreased muscle strength
Soft tissue swelling
Skin changes consistent with pressure necrosis
Hyperthermia, hypothermia, and electrical injuries
Crush injuries or deformities in long bones
*
*
Rhabdomyolysis and Acute Kidney Injury | NEJM
https://www.nejm.org/doi/full/10.1056/nejmra0801327
by X Bosch – ?2009 – ?Cited by 847 –
May 18, 2011 – Review Article from The New England Journal of Medicine Rhabdomyolysis and Acute Kidney Injury.
*
*
Rhabdomyolysis – Mayo Clinic – YouTube
Video for rhabdomyolysis
? 2:25
https://www.youtube.com/watch?v=Hy0uEPo8-7w
Jun 22, 2011 – Uploaded by Mayo Clinic
Earlier this year, thirteen football players from the University of Iowa were hospitalized with Rhabdomyolysis …
*
*
Database Search Results for Rhabdomyolysis
Google Scholar
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C39&q=rhabdomyolysis+&btnG=
Google Books
https://www.google.com/search?tbm=bks&q=rhabdomyolysis+
Penn State Summon Search
https://tinyurl.com/ybqpxcub
Book / eBook (6,085) Include Exclude
Book Chapter (4,393) Include Exclude
Book Review (2,524) Include Exclude
Conference Proceeding (428) Include Exclude
Dissertation/Thesis (701) Include Exclude
Electronic Resource (3) Include Exclude
Government Document (6) Include Exclude
Journal / eJournal (32) Include Exclude
Journal Article (43,115) Include Exclude
Magazine (3) Include Exclude
Magazine Article (2,273) Include Exclude
Manuscript (15) Include Exclude
Market Research (5) Include Exclude
Newsletter (3,344) Include Exclude
Newspaper Article (10,196) Include Exclude
Pamphlet (4) Include Exclude
Paper (13) Include Exclude
Patent (93) Include Exclude
Poster (2) Include Exclude
Presentation (2) Include Exclude
Publication (3) Include Exclude
Reference (1,534) Include Exclude
Report (237) Include Exclude
Research Guide (2) Include Exclude
Special Collection (2) Include Exclude
Streaming Audio (1) Include Exclude
Streaming Video (3) Include Exclude
Student Thesis (2) Include Exclude
Technical Report (24) Include Exclude
Trade Publication Article (239) Include Exclude
Transcript (118) Include Exclude
Web Resource (174) Include Exclude
Google Domain Limited Web Search (GOV)
https://tinyurl.com/ydcy7paf
Google Domain Limited Web Search (PUBMED)
https://tinyurl.com/yax8zk5m
Google Domain Limited Web Search (SCIENCEDIRECT)
https://tinyurl.com/y8xbtthl
.
.
WEBBIB1718
http://tinyurl.com/yaevofzf
.
.
Sincerely,
David Dillard
Temple University
(215) 204 – 4584
jwne@…
*
*
RESEARCH GUIDE DIRECTORY
https://sites.google.com/site/researchguideresourcesongsites/
Net-Gold
https://groups.io/g/Net-Gold
http://listserv.temple.edu/archives/net-gold.html
https://groups.io/org/groupsio/Net-Gold/archives
Google Sites Research Guides AND Discussion Group Directory
http://tinyurl.com/ngda2hk
OR
https://sites.google.com/site/researchguidesonsites/
FAKE NEWS
https://sites.google.com/site/fakenewsresearchguide/
RESEARCH PAPER WRITING
https://sites.google.com/site/howtowriteasuperresearchpaper/
EMPLOYMENT
https://sites.google.com/site/employmentsources/
INTERNSHIPS
https://sites.google.com/site/internshipsarticles/home/internships-main-sitemap
Social Work and Social Issues Discussion Group
https://groups.io/g/social-work
Tourism Discussion Group
https://groups.io/g/Tourism
Blog
https://educatorgold.wordpress.com/
Articles by David Dillard
https://sites.google.com/site/daviddillardsarticles/
Twitter: davidpdillard
SPORT-MED
https://www.jiscmail.ac.uk/lists/sport-med.html
http://listserv.temple.edu/archives/sport-med.html
https://groups.io/g/SportMed/topics